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Buijsse B, Feskens EJM, Kok FJ, Kromhout D. Cocoa intake, blood pressure, and cardiovascular mortality. Arch Intern Med 2006;166:411-7.

Burke, L.M. (1999) The role of chocolate in exercise performance. In: Chocolate and Cocoa: Health &Nutrition (Ed. By Knight, I.). Blackwell Science, Oxford. Keys, A. (1970) Coronary heart disease in 7 countries. Circulation 41 (Suppl. 1), 1-221.

Engler, M.B., Engler, M.M., Chen, C.Y., Malloy, M.J., Browne, A., Chiu, E., Kwak, HK, Milbury, P., Paul SM, Blumberg, J. Mietus-Snyder, M. Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. Journal of the American College of Nutrition 23(3),197-204.

Engler, M.B., Engler, M.M. (2004) The vasculoprotective effects of flavonoid-rich cocoa and chocolate. Nutrition Research, 24(9) : 695-706

Engler, M.B., Engler, M.M., The emerging role of flavonoid-rich cocoa and chocolate in cardiovascular health and disease. Nutrition Reviews 2006 Mar; 64(3) ; 109-18

Fisher ND et al. Flavanol-rich cocoa induces nitric oxide-dependent vasodilation in healthy humans. J Hypertens 2003 21:2281-6.

Fisher NDL, Hughes M, Gerhard-Herman M, Hollenberg NK. Flavanol-rich cocoa induces nitric oxide-dependent vasodilation in healthy humans. J Hypertens 2003;21:2281-6.

Fraga CG, Actis-Goretta L, Ottaviani JI, Carrasquedo F, Lotito SB, Lazarus S, Schmitz HH, Keen CL. Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players. Clin Dev Immunol 2005 Mar;12(1):11-7.

Geleijnse JM, Grobbee DE, Kok FJ. Impact of dietary and lifestyle factors on the prevalence of hypertension in Western populations. J Hum Hypertens 2005 Dec;19 Suppl 3:S1-4.

Grassi D, Lippi C, Necozione S, Desideri G, Ferri C. Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons. Am J Clin Nutr 2004;81:611-4.

Grassi D, Necozione S, Lippi C, Croce G, Valeri L, Pasqualetti P, Desideri G, Blumberg JB, Ferri C. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension 2005 Aug;46(2):398-405.

Heiss C, Dejam A, Kleinbongard P, Schewe T, Sies H, Kelm M. Vascular effects of cocoa rich in flavan-3-ols. JAMA 2003;290:1030-1.

Heiss C, et al. Vascular effects of cocoa rich in flavan-3-ols. JAMA 2003 290:1030-1.

Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993;342:1007-1011.

Hollenberg N, Martinez G, McCullough M, et al. Aging, acculturation, salt intake, and hypertension in the Kuna of Panama. Hypertension 1997;29:171-6.

Holt RR, Lazarus SA, Sullards MC, et al. Procyanidin dimmer B2 (epicatechin-[4beta-8]-epicatechin) in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr 2002;76:798-804.

Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 2005 Jan;81 (1 Suppl):313S-316S.

Kondo K, Hirano R, Matsumoto A, Igarashi O, Itakura H. (1996) Inhibition of LDL oxidation by cocoa. Lancet 348, 1514.

Kozikowski AP, Tuckmantel W, Bottcher G, Romanczyk LJ Jr. Studies in polyphenol chemistry and bioactivity. 4.(1) Synthesis of trimeric, tetrameric, pentameric, and higher oligomeric epicatechin-derived procyanidins having all-4beta,8-interflavan connectivity and their inhibition of cancer cell growth through cell cycle arrest. J Org Chem 2003 Mar 7;68(5):1641-58.

Kurosawa T, Itoh F, Nozaki A, Nakano Y, Katsuda S, Osakabe N, Tsubone H, Kondo K, Itakura H. Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits. J Atheroscler Thromb 2005;12(1):20-8.

Lee KW, et al. Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J. Agric Food Chem 2003 51:7292-5.

Mao TK, Powell JJ, Van de Water J, Keen CL, Schmitz HH, Gershwin ME. The influence of cocoa procyanidins on the transcription of interleukin-2 in peripheral blood mononuclear cells. Int J Immunol 1999;15(1):23-9.

Mao TK, Van de Water J, Keen CL, Schmitz HH, Gershwin ME. Effect of cocoa flavanols and their related oligomers on the secretion of interleukin-5 in peripheral blood mononuclear cells. J Med Food 2002;5(1):17-22.

Murphy KJ, Chronopoulos AK, Singh I, et al. Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am J Clin Nutr 2003;77:1466-73.

Osakabe N, Baba S, Yasuda A, Iwamoto T, Kamiyama M, Takizawa T, Itakura H, Kondo K. Daily cocoa intake reduces the susceptibility of low density lipoprotein to oxidation as demonstrated in healthy human volunteers. Free Radic Res 2001;34:93-99.

Osakabe N, et al. Catechins and their oligomers linked by C4 - C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp Biol Med 2002 227:51-6.

Osawa, T. (1995) Antioxidation and antimutagenic reactions of polyphenols contained in chocolate cocoa. International Symposium on Nutrition of Chocolate and Cocoa, Japan.

Pearson DA, Holt RR, Rein D, Paglieroni T, Schmitz HH, Keen CL. Flavanols and platelet reactivity. Clin Dev Immunol. 2005 Mar;12(1):1-9.

Pearson D, Paglieroni T, Rein D, et al. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. Thromb Res 2002;106:191-97.

Ramiro E, Franch A, Catellote C, Andres-Lacueva C, Izquierdo-Pulido M, Castell M. Effect of Theobroma cacao flavonoids on immune activation of a lymphoid cell line. Br J Nutr 2005;93:859-866.

Ramljak D, Romanczyk LJ, Metheny-Barlow LJ, Thompson N, Knezevic V, Galperin M, Ramesh A, Dickson RB. Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells. Mol Cancer Ther 2005 Apr;4(4):537-46.

Rein D, Paglieroni TG, Wun T, et al. Cocoa inhibits platelet activation and function. Am J Clin Nutr 2000;72:30-35.

Rupien John R. (1999) Overview of the Nutritional Benefits of Cocoa and Chocolate. In: Chocolate and Cocoa: Health & Nutrition (Ed. By Knight, I.).Blackwell Science, Oxford.

Sabongi C, Suzuki N, Sakane T. Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro. Cell Immunol 1997;177:129-36.

Schewe T, Sadik C, Klotz L, Yoshimoto T, Kuhn H, Sies H. Polyphenols of cocoa: Inhibition of mammalian 15-lipoxygenase. Biol Chem 2001 Dec;382:1687-96.

Schramm DD, Karim M, Schrader HR, Holt RR, Kirkpatrick NJ, Polagruto JA, Ensunsa JL, Schmitz HH, Keen CL. Food effects on the absorption and pharmacokinetics of cocoa flavanols. Life Sciences 2003;73:857-869.

Schramm DD, Wang JF, Holt RR, et al. Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am J Clin Nutr 2001;73:36-40.

Schroeter H, Holt RR, Orozco TJ, Schmitz HH, Keen CL. Nutrition: milk and absorption of dietary flavanols. Nature 2003;426:787-8

Serafini M, Bugianesi R, Maiani G, Valtuena S, De Santis S, Crozier A. Plasma antioxidants from chocolate. Nature 2003 Aug 28;424(6952):1013.

Sies H, Schewe T, Heiss C, Kelm M. Cocoa polyphenols and inflammatory mediators. Am J Clin Nutr 2005 Jan;81(1 Suppl):304S-312S.

Steinberg FM, Bearden MM, Keen CL. Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc 2003 Feb;103(2):215-23.

Steffen Y, et al. Epicatechin protects endothelial cells against oxidized LDL, and maintains NO synthase. Biochem Biophys Res Commun 2005 331:1277-83

Taubert D, Berkels R, Roesen R, Klaus W. Chocolate and blood pressure in elderly individuals with isolated systolic hypertension. JAMA 2003;290:1029-30.

Unno K, Takabayashi F, Kishido T, Oku N. Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10). Exp Gerontol 2004 Jul;39(7):1027-34.

Vlachopoulos C, Aznaouridis K, Alexopoulos N, Economou E, Andreadou I, Stefanadis C. Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens 2005 Jun;18(6):785-91.

Vita JA. Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 2005 81:292S-7S.

Wan Y, et al. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am J Clin Nutr 2001 74:596-602.

Wan Y, Vinson JA, Etherton TD, Proch J, Lazarus S, Kris-Etherton P. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am J Clin Nutr 2001;74:596-602.

Wang JF, et al. A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage. J Nutr 2000 130:2115S-9S.

Wang JF, Schramm DD, Holt RR,Ensunsa JL, Fraga CG, Schmitz HH, Keen CL. A Dose Response Effect from Chocolate Consumption on Plasma Epicatechin and Oxidative Damage. J Nutr 2000;130:2115S-9S.

Weisburger JH. Chemopreventive effects of cocoa polyphenols on chronic diseases. Exp Biol Med (Maywood) 2001 Nov;226(10):891-7.

Wiswedel I, Hirsch D, Kropf S, Gruening M, Pfister E, Schewe T, Sies H. Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans. Free Radic Biol Med 2004 Aug 1;37(3):411-21.

Wu X, et al. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem 2004;52:4026-37.